uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Multidisciplinary treatment of patients with rectal cancer: Development during the past decades and plans for the future
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
2012 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 117, no 2, 225-236 p.Article in journal (Refereed) Published
Abstract [en]

In rectal cancer treatment, both the local primary and the regional and systemic tumour cell deposits must be taken care of in order to improve survival. The three main treatments, surgery, radiotherapy, and chemotherapy, each with their own advantages and limitations, must then be combined to improve results. Several large randomized trials have shown that combinations of the modalities have markedly reduced the loco-regional recurrences, but have not yet had any major influence on overall survival. The best integration of the weakest modality, to date the drugs (conventional cytotoxics and biologicals), is not known. A new generation of trials exploring the best sequence of treatments is required. Furthermore, treatment of rectal cancer is administered to populations of individuals, based upon clinical factors and imaging, and can presently not be further individualized. There is an urgent need to develop response predictors.

Place, publisher, year, edition, pages
2012. Vol. 117, no 2, 225-236 p.
Keyword [en]
Chemoradiotherapy, chemotherapy, local control, multidisciplinary, organ preservation, radiotherapy, randomized trials, rectal cancer
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-174365DOI: 10.3109/03009734.2012.658974ISI: 000302949200016OAI: oai:DiVA.org:uu-174365DiVA: diva2:528108
Available from: 2012-05-24 Created: 2012-05-15 Last updated: 2012-05-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Glimelius, Bengt
By organisation
In the same journal
Upsala Journal of Medical Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 134 hits
ReferencesLink to record
Permanent link

Direct link