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Contrast enhancement of manganese-hydroxypropyl-tetraacetic acid, an MR contrast agent with potential for detecting differences in myocardial blood flow
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlstrom)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlstrom)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlstrom)
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2006 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 24, no 4, 858-863 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To determine whether the contrast agent MnHPTA has potential for detecting differences in myocardial blood flow.

Materials and Methods: R1 in the myocardium was calculated from MR signal intensity measurements in 18 pigs after intravenous injection of 5, 15, or 25 mu mol MnHPTA/kg body weight. Measurements were made in each animal after administration at rest and during dobutamine-induced stress.

Results: A difference of approximately 0.1 see(-1) in the R1 increase between rest and stress still remained 31 minutes after administration of 25 mu mol MnHPTA/kg body weight. When two consecutive MnHPTA injections were performed, the second injection induced a lower R1 increase than the corresponding first injection.

Conclusion: MnHPTA at a dose of 25 mu mol/kg body weight (b.w.) has the potential to detect perfusion differences in myocardium. When two consecutive injections of MnHPTA were administered, the RI change after the second injection was affected by the earlier administration. Therefore, a protocol including more than one administration is not ideal for this contrast agent.

Place, publisher, year, edition, pages
2006. Vol. 24, no 4, 858-863 p.
Keyword [en]
manganese, magnetic resonance, myocardium, contrast agent, animal study
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-25041DOI: 10.1002/jmri.20718ISI: 000240882000017PubMedID: 16958069OAI: oai:DiVA.org:uu-25041DiVA: diva2:52815
Available from: 2007-02-09 Created: 2007-02-09 Last updated: 2017-12-07Bibliographically approved

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Eriksson, RolfJohansson, LarsBjerner, TomasAhlström, Håkan

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