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Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
2012 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 117, no 2, 166-177 p.Article, review/survey (Refereed) Published
Abstract [en]

Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal role in providing critical cytokines and cell-cell interactions to support the growth and survival of the MM tumor clone. The pathogenesis of MM is, however, only fragmentarily understood. Detailed genomic analysis reveals a heterogeneous and complex pattern of structural and numerical chromosomal aberrations. In this review we will discuss some of the recent results on the functional role and potential clinical use of the IGF-1R, one of the major mediators of growth and survival for MM. We will also describe some of our results on epigenetic gene silencing in MM, as it may indeed constitute a novel basis for the understanding of tumor initiation and maintenance in MM and thus may change the current view on treatment strategies for MM.

Place, publisher, year, edition, pages
2012. Vol. 117, no 2, 166-177 p.
Keyword [en]
Epigenetics, IGF-1, multiple myeloma
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-174659DOI: 10.3109/03009734.2012.659293ISI: 000302949200010OAI: oai:DiVA.org:uu-174659DiVA: diva2:528456
Available from: 2012-05-25 Created: 2012-05-24 Last updated: 2017-12-07Bibliographically approved

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