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Myc proteins in brain tumor development and maintenance
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
2012 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 117, no 2, 122-131 p.Article, review/survey (Refereed) Published
Abstract [en]

Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.

Place, publisher, year, edition, pages
2012. Vol. 117, no 2, 122-131 p.
Keyword [en]
Brain tumors, molecular biology, oncogenes, pediatrics, protein phosphorylation, tumor biology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-174655DOI: 10.3109/03009734.2012.658975ISI: 000302949200006OAI: oai:DiVA.org:uu-174655DiVA: diva2:528459
Available from: 2012-05-25 Created: 2012-05-24 Last updated: 2012-05-28Bibliographically approved

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Swartling, Fredrik J.
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