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Effect of degree of methoxylation and particle size on compression properties and compactibility of pectin powders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2012 (English)In: Pharmaceutical development and technology (Print), ISSN 1083-7450, E-ISSN 1097-9867, Vol. 17, no 3, 333-343 p.Article in journal (Refereed) Published
Abstract [en]

This study examines the effect of the degree of methoxylation (DM) and particle size on compression properties and compactibility of pectin powders. A powder classification system based on sequential handling of compression parameters was applied. A single size fraction (90-125 mu m) of pectin powders with DM values ranging from 5-72% was studied. For DM 25%, the effect of different particle size fractions (180-250, 125-180, 90-125, 63-90, 45-63, <45 mu m) were investigated. Compression parameters were derived based on time-resolved force-displacement data using Heckel, Kawakita and Shapiro equations. Volume-specific surface area was estimated for powders and tablets. Tablet tensile strength was determined. It was found that all pectin powders displayed low degrees of particle rearrangement and relatively low degrees of fragmentation (class IIA materials). Pectin particles were found to be relatively soft, with a tendency towards softer particles for pectins of higher DM. The overall variation in fragmentation and deformation behavior was limited. Both DM and initial particle size affected the tensile strength of pectin tablets. The difference in surface hydrophobicity caused by the DM was suggested as being responsible for the variation in the mechanical strengths. The study shows that pectin grades with DM <= 40% are potential direct compression excipients.

Place, publisher, year, edition, pages
2012. Vol. 17, no 3, 333-343 p.
Keyword [en]
Sequential handling of compression parameters, particle rearrangement, fragmentation propensity, plastic deformation, tensile strength
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-174712DOI: 10.3109/10837450.2010.535831ISI: 000302916500008OAI: oai:DiVA.org:uu-174712DiVA: diva2:528705
Available from: 2012-05-28 Created: 2012-05-25 Last updated: 2017-12-07Bibliographically approved

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Alderborn, Göran

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