uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Whole blood viscosity and erythrocyte deformability are related to endothelium-dependent vasodilation and coronary risk in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2012 (English)In: Clinical hemorheology and microcirculation, ISSN 1386-0291, Vol. 50, no 4, 301-311 p.Article in journal (Refereed) Published
Abstract [en]

It has previously been shown that a high hemoglobin value, a major determinant of whole blood viscosity (WBV), predicts cardiovascular events. One putative mechanism might be an impaired endothelial function. Erythrocyte deformability is another rheologic feature of the erythrocyte being of importance for the flow properties of the blood, especially in the capillaries. The present study evaluates the relationships between blood viscosity, erythrocyte deformability assessed as erythrocyte fluidity (EF), coronary risk and endothelial vasodilatory function. In the population-based PIVUS study (1016 subjects aged 70); endothelium-dependent vasodilation (EDV) was evaluated by the invasive forearm technique with acetylcholine given in the brachial artery and the brachial artery ultrasound technique with measurement of flow-mediated dilatation (FMD). WBV, plasma viscosity (PV) and EF were measured in a random sample of 573 subjects. WBV and PV were positively and EF negatively related to Framingham risk score. EDV was inversely related to both whole blood and plasma viscosity. FMD was not related to any rheologic variable. In multiple regression analyses WBV and EF were significantly related to EDV independently of gender, hypertension, smoking, hypercholesterolemia, obesity and diabetes. Acetylcholine-induced vasodilation in the forearm, but not FMD, was negatively related to whole blood viscosity and positively related to EF independently of traditional risk factors in elderly subjects, indicating a pathophysiological link between impaired hemorheology and coronary risk.

Place, publisher, year, edition, pages
2012. Vol. 50, no 4, 301-311 p.
Keyword [en]
Blood viscosity, endothelium, erythrocyte deformability, coronary risk, vasodilation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-174983DOI: 10.3233/CH-2011-1505ISI: 000303443300007OAI: oai:DiVA.org:uu-174983DiVA: diva2:529725
Available from: 2012-05-31 Created: 2012-05-30 Last updated: 2012-05-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sandhagen, BoLind, Lars
By organisation
Clinical PhysiologyDepartment of Medical Sciences
In the same journal
Clinical hemorheology and microcirculation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 160 hits
ReferencesLink to record
Permanent link

Direct link