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Standard Error of Empirical Bayes Estimate in NONMEM (R) VI
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2012 (English)In: Korean Journal of Physiology & Pharmacology, ISSN 1226-4512, Vol. 16, no 2, 97-106 p.Article in journal (Refereed) Published
Abstract [en]

The pharmacokinetics/pharmacodynamics analysis software NONMEM (R) output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM (R) VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled data for demonstration and to evaluate performance. The computed standard error is in general similar to the results from other post-processing methods and the degree of difference, if any, depends on the employed estimation options.

Place, publisher, year, edition, pages
2012. Vol. 16, no 2, 97-106 p.
Keyword [en]
NONMEM, Standard error of empirical bayes estimate, Nonlinear mixed effects modeling
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-174970DOI: 10.4196/kjpp.2012.16.2.97ISI: 000303697600003OAI: oai:DiVA.org:uu-174970DiVA: diva2:529851
Available from: 2012-05-31 Created: 2012-05-30 Last updated: 2012-05-31Bibliographically approved

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Savic, Radojka M.Karlsson, Mats O
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Department of Pharmaceutical Biosciences
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