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Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence.
Laboratori of Neurofarmacologia, Facultat de Ciéncies de la Salut i de la Vida, Universitat Pompeu Fabra, C/Doctor Aiguader 80, 08003 Barcelona, Spain.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Laboratori of Neurofarmacologia, Facultat de Ciéncies de la Salut i de la Vida, Universitat Pompeu Fabra, C/Doctor Aiguader 80, 08003 Barcelona, Spain.
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2006 (English)In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 50, no 7, 788-806 p.Article in journal (Refereed) Published
Abstract [en]

The identification of the possible factors that might enhance the risk of developing drug addiction and related motivational disorders is crucial to reduce the prevalence of these problems. Here, we examined in mice whether the exposure to the anabolic-androgenic steroid nandrolone would affect the pharmacological and motivational effects induced by Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of Cannabis sativa. Mice received nandrolone using pre-exposure (during 14 days before THC treatment) or co-administration (1h before each THC injection) procedures. Both nandrolone treatments did not modify the acute anti nociceptive, hypothermic and hypolocomotor effects of THC or the development of tolerance after chronic THC administration. Nandrolone pre-exposure blocked THC- and food-induced conditioned place preference and increased the somatic manifestations of THC withdrawal precipitated by the CB1 cannabinoid antagonist rimonabant (SR141617A). The aversive effects of THC were not changed by nandrolone. Furthermore, nandrolone pre-exposure attenuated the anxiolytic-like effects of a low dose of THC without altering the anxiogenic-like effects of a high dose in the lit/dark box, open field and elevated plus-maze. Biochemical experiments showed that chronic nandrolone treatment did not modify CB1 receptor binding and GTP-binding protein activation in the caudate-putamen and cerebellum. Taken together, our results suggest that chronic nandrolone treatment alters behavioural responses related to cannabinoid addictive properties.

Place, publisher, year, edition, pages
2006. Vol. 50, no 7, 788-806 p.
Keyword [en]
Anabolic Agents/*administration & dosage, Androgens/*administration & dosage, Animals, Cannabinoids/metabolism/pharmacology, Dose-Response Relationship; Drug, Male, Mice, Motor Activity/drug effects/physiology, Nandrolone/*administration & dosage, Pain Measurement/drug effects/methods, Protein Binding/drug effects/physiology, Receptor; Cannabinoid; CB1/metabolism, Substance-Related Disorders/*drug therapy/metabolism/psychology, Tetrahydrocannabinol/metabolism/*pharmacology
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Pharmaceutical Sciences
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URN: urn:nbn:se:uu:diva-25315DOI: 10.1016/j.neuropharm.2005.11.017ISI: 000238724700003PubMedID: 16443242OAI: oai:DiVA.org:uu-25315DiVA: diva2:53089
Available from: 2007-02-12 Created: 2007-02-12 Last updated: 2017-12-07Bibliographically approved

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