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Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET Platform. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
2012 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 39, no 4, 484-501 p.Article in journal (Refereed) Published
Abstract [en]

Visualizing the neuropathological hallmarks amyloid plaques and neurofibrillary tangles of Alzheimer's disease in vivo using positron emission tomography (PET) or single photon emission computed tomography will be of great value in diagnosing the individual patient and will also help in our understanding of the disease. The successful introduction of [C-11]PIB as a PET tracer for the amyloid plaques less than 10 years ago started an intensive research, and numerous new compounds for use in molecular imaging of the amyloid plaques have been developed. The candidates are based on dyes like thioflavin T, Congo red and chrysamine G, but also on other types such as benzoxazoles, curcumin and stilbenes. In the present review, we present methods of the radiochemistry and preclinical evaluation as well as the main properties of some of these compounds.

Place, publisher, year, edition, pages
2012. Vol. 39, no 4, 484-501 p.
Keyword [en]
Alzheimer's disease, Amyloid plaques, Molecular imaging, Positron emission tomography, Preclinical evaluation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-175208DOI: 10.1016/j.nucmedbio.2011.10.007ISI: 000303790600005OAI: oai:DiVA.org:uu-175208DiVA: diva2:530956
Available from: 2012-06-05 Created: 2012-06-04 Last updated: 2017-12-07Bibliographically approved

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Svedberg, Marie M.Hall, Håkan

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