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Adherence and discontinuation of adjuvant hormonal therapy in breast cancer patients: a population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg.
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2012 (English)In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 133, no 1, 367-373 p.Article in journal (Refereed) Published
Abstract [en]

Adherence to long-term pharmacological treatment for chronic conditions is often less than optimal. Till date, a limited number of population-based studies have assessed adherence to adjuvant hormonal therapy in breast cancer, a therapy with proven benefits in terms of reductions of recurrence and mortality. We aimed to examine rates of adherence and early discontinuation in Sweden where prescribed medications are subsidized for all residents and made available at reduced out-of-pocket costs. Individual-level data were obtained from Regional Clinical Quality Breast Cancer Registers, the Swedish Prescribed Drug Register, and several other population-based registers. Multivariate logistic regression was used to analyze factors associated with adherence to prescribed medication for a period of 3 years. Between January 1 and December 31, 2005, 1,741 patients in central Sweden were identified with estrogen receptor positive breast cancer, and at least one prescription dispensation of either tamoxifen or an aromatase inhibitor. Of these women, 1,193 (69%) were fully adherent to therapy for 3 years (medication possession ratio of 80% or higher and a maximum of 180 days between refills). During the 3-year follow-up, 215 women (12%) had prematurely discontinued therapy. Adherence was positively associated with younger age, large tumor size, being married, and being born in the Nordic countries, while no clear association was observed with education or income. During the 3 years of follow-up, 31% of women were non-adherent to therapy. Further efforts must be undertaken to promote adherence over the entire recommended treatment period.

Place, publisher, year, edition, pages
2012. Vol. 133, no 1, 367-373 p.
Keyword [en]
Breast cancer, Tamoxifen, Aromatase inhibitors, Adherence, Sweden
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-175202DOI: 10.1007/s10549-012-1961-4ISI: 000303509200035OAI: oai:DiVA.org:uu-175202DiVA: diva2:530987
Available from: 2012-06-05 Created: 2012-06-04 Last updated: 2012-06-05Bibliographically approved

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Ahlgren, JohanLindman, HenrikBergkvist, Leif
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Centre for Research and Development, GävleborgOncologyCentre for Clinical Research, County of Västmanland
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