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Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Chemical Biology.
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2012 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 77, no 10, 4671-4678 p.Article in journal (Refereed) Published
Abstract [en]

Several novel nucleoside analogues as potential inhibitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via selective coupling of an appropriate nucleobase at different positions of an orthogonally protected imino sugar as a common precursor. This synthetic strategy offers a straightforward protocol for the assembly of imino sugar containing nucleosides, establishing a new repertoire of molecules as potential therapeutics.

Place, publisher, year, edition, pages
2012. Vol. 77, no 10, 4671-4678 p.
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-175612DOI: 10.1021/jo3004452ISI: 000304129400017OAI: oai:DiVA.org:uu-175612DiVA: diva2:532870
Available from: 2012-06-12 Created: 2012-06-11 Last updated: 2012-07-11Bibliographically approved

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Chattopadhyaya, Jyoti
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