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Induction of epithelial-mesenchymal transition by transforming growth factor β
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2012 (English)In: Seminars in Cancer Biology, ISSN 1044-579X, E-ISSN 1096-3650, Vol. 22, no 5-6, 446-454 p.Article in journal (Refereed) Published
Abstract [en]

Transforming growth factor β (TGFβ) is implicated in human malignancy. Tumors may escape the tumor suppressor activity of TGFβ by mutating some of its signaling components. Carcinoma and stromal cells produce high amounts of TGFβ which promotes epithelial-mesenchymal transition (EMT), tumor cell invasiveness and tumor angiogenesis, while suppressing immune responses against the tumor. Thus, TGFβ has tumor suppressive as well as tumor promoting effects supporting metastasis. TGFβ elicits the EMT response by activating complementary signaling cascades that mobilize embryonic transcription factors that reprogram the epithelial cell so that it acquires both progenitor-like, pro-motility and mesenchymal features. Such nuclear reprogramming of carcinoma cells involves epigenetic and transcriptional regulation, the activity of miRNAs, and modulation of RNA splicing and mRNA translation, leading to the expression of key intracellular and membrane proteins together with a large pool of secreted factors that mediate and account for the phenotypic changes that accompany EMT.

Place, publisher, year, edition, pages
2012. Vol. 22, no 5-6, 446-454 p.
Keyword [en]
Epithelial–mesenchymal transition, Signal transduction, Transcription factor, Transforming growth factor β, Tumor invasiveness
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-175966DOI: 10.1016/j.semcancer.2012.04.002ISI: 000309898600013PubMedID: 22548724OAI: oai:DiVA.org:uu-175966DiVA: diva2:533739
Available from: 2012-06-14 Created: 2012-06-14 Last updated: 2017-12-07Bibliographically approved

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Moustakas, AristidisHeldin, Carl-Henrik

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Department of Medical Biochemistry and MicrobiologyLudwig Institute for Cancer ResearchScience for Life Laboratory, SciLifeLab
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