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Genome-wide mechanisms of Smad binding
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab. Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2013 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 32, no 13, 1609-1615 p.Article, review/survey (Refereed) Published
Abstract [en]

A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We describe current knowledge of cell-type-specific binding patterns of Smad proteins and mechanisms of transcriptional regulation, obtained from recent studies on genome-wide binding sites of Smad molecules. We also discuss potential application of the genome-wide analyses for cancer research, which will allow clarification of the complex mechanisms occurring during cancer progression, and the identification of potential biomarkers for future cancer diagnosis, prognosis and therapy.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013. Vol. 32, no 13, 1609-1615 p.
Keyword [en]
Nanofluidics, passivation, antifouling, lipid bilayer, protein-DNA interactions, single molecules
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-175982DOI: 10.1038/onc.2012.191ISI: 000316855800001PubMedID: 22614010OAI: oai:DiVA.org:uu-175982DiVA: diva2:533765
Available from: 2012-06-14 Created: 2012-06-14 Last updated: 2017-12-07Bibliographically approved

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Morikawa, MasatoHeldin, Carl-Henrik

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