uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi)
2012 (English)In: Clinics, ISSN 1807-5932, Vol. 67, no S 1, 109-112 p.Article, review/survey (Refereed) Published
Abstract [en]

Neuroendocrine tumors are a heterogeneous group of malignancies that present a diagnostic challenge. The majority of patients (more than 60%) present with metastatic disease at diagnosis. The diagnosis is based on histopathology, imaging, and circulating biomarkers. The histopathology should contain specific neuroendocrine markers such as chromogranin A, synaptophysin, and neuron-specific enolase and also an estimate of the proliferation by Ki-67 (MIB-1). Standard imaging procedures consist of computed tomography or magnetic resonance imaging together with somatostatin receptor scintigraphy. 68Ga-DOTA-octreotate scans will in the future replace somatostatin receptor scintigraphy because they have higher specificity and sensitivity. Other positron imaging tomographic scanning tracers that will come into clinical use are 18F-DOPA and 11C-5HTP. Neuroendocrine tumors secrete many different peptides and amines that can be used as circulating biomarkers. The most useful general marker is chromogranin A, which is both a diagnostic and prognostic marker in most neuroendocrine tumors. However, there is still a need for improved biomarkers for early detection and follow-up of patients during treatment. In addition, molecular imaging can be further developed for both detection and evaluation of treatment.

Place, publisher, year, edition, pages
2012. Vol. 67, no S 1, 109-112 p.
Keyword [en]
Chromogranin A, 68Ga-DOTATOC, Somatostatin Receptor Scintigraphy, Tumor Node Metastasis Staging, Grading
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-175980DOI: 10.6061/clinics/2012(Sup01)18ISI: 000304082400018OAI: oai:DiVA.org:uu-175980DiVA: diva2:533782
Available from: 2012-06-14 Created: 2012-06-14 Last updated: 2012-06-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Öberg, Kjell
By organisation
Department of Medical Sciences
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 185 hits
ReferencesLink to record
Permanent link

Direct link