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Recruit the lung before titrating the right positive end-expiratory pressure to protect it
2009 (English)In: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 13, no 3, 134- p.Article in journal (Refereed) Published
Abstract [en]

The optimal level of positive end-expiratory pressure (PEEP) in acute respiratory distress syndrome patients is still controversial and has gained renewed interest in the era of 'lung protective ventilation strategies'. Despite experimental evidence that higher levels of PEEP protect against ventilator-induced lung injury, recent clinical trials have failed to demonstrate clear survival benefits. The open-lung protective ventilation strategy combines lung recruitment maneuvers with a decremental PEEP trial aimed at finding the minimum level of PEEP that prevents the lung from collapsing. This approach to PEEP titration is more likely to exert its protective effects and is clearly different from the one used in previous clinical trials.

Place, publisher, year, edition, pages
2009. Vol. 13, no 3, 134- p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-176050DOI: 10.1186/cc7763PubMedID: 19480645OAI: oai:DiVA.org:uu-176050DiVA: diva2:534071
Available from: 2012-06-15 Created: 2012-06-15 Last updated: 2017-12-07Bibliographically approved

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