Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.
2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 47, 19980-5 p.Article in journal (Refereed) Published
We analyzed antibody responses in sera from feline immunodeficiency virus (FIV)-infected and uninfected cats. A strong antiviral response to the viral surface glycoprotein (SU) was noted in both natural and experimental infections. In addition, 143 of 226 FIV-infected animals (63%) also expressed antibodies to the primary binding receptor, CD134, whereas cats infected with other feline RNA viruses, including calicivirus, coronavirus, herpesvirus, and feline leukemia virus, did not. Both affinity-purified anti-CD134 and anti-SU antibodies blocked FIV infection ex vivo. FACS analyses revealed that the anti-CD134 antibodies bound to a cryptic epitope on the receptor that was only exposed when SU bound to CD134. Anti-CD134 binding caused displacement of SU from the surface of the cell and inhibition of infection. The presence of antibodies to CD134 correlated with lower virus loads and a better overall health status in FIV(+) cats, whereas anti-SU antibodies were present independent of health status. The findings are consistent with a role for antireceptor antibodies in protection from virus spread and disease progression.
Place, publisher, year, edition, pages
2009. Vol. 106, no 47, 19980-5 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-176105DOI: 10.1073/pnas.0911307106PubMedID: 19901342OAI: oai:DiVA.org:uu-176105DiVA: diva2:534279