Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
2012 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, Vol. 50, no 5, 845-851 p.Article in journal (Refereed) Published
Background: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.
Methods: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.
Results: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.
Conclusions: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.
Place, publisher, year, edition, pages
2012. Vol. 50, no 5, 845-851 p.
biomarker, children, immunoassay, pediatric, reference interval, reference range
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-176835DOI: 10.1515/cclm-2011-0787ISI: 000304434200011OAI: oai:DiVA.org:uu-176835DiVA: diva2:537280