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Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (biokemisk struktur och funktion)
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2012 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, Vol. 50, no 5, 845-851 p.Article in journal (Refereed) Published
Abstract [en]

Background: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.

Methods: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.

Results: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.

Conclusions: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.

Place, publisher, year, edition, pages
2012. Vol. 50, no 5, 845-851 p.
Keyword [en]
biomarker, children, immunoassay, pediatric, reference interval, reference range
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-176835DOI: 10.1515/cclm-2011-0787ISI: 000304434200011OAI: oai:DiVA.org:uu-176835DiVA: diva2:537280
Available from: 2012-06-26 Created: 2012-06-26 Last updated: 2012-06-26Bibliographically approved

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Ridefelt, PeterGustafsson, JanHellberg, Dan
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Department of Medical SciencesPediatricsObstetrics and GynaecologyCenter for Clinical Research Dalarna
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Clinical Chemistry and Laboratory Medicine
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