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DHEA and DHEA-S response to acute psychosocial stress in healthy men and women
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
2012 (English)In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 90, no 2, 143-149 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S in healthy men and women. Twenty men and 19 women (age 30-50 years) underwent Trier Social Stress Test (TSST). Physiological measurements were performed before, directly after the stress test and after 30 mins of recovery. In both men and women, significantly elevated DHEA and DHEA-S levels were observed in response to the stressor. There was a large inter-individual variation in the magnitude of the response, especially for DHEA but no statistical difference between men and women. Magnitude of the change in the levels of DHEA was found to be positively associated with the magnitude of the changes in ACTH, cortisol and heart rate. Furthermore, the results of this study suggest that the capacity to secrete DHEA and DHEA-S during acute psychosocial stress declines with age.

Place, publisher, year, edition, pages
2012. Vol. 90, no 2, 143-149 p.
Keyword [en]
DHEA, DHEA-S, Acute stress, Trier Social Stress Test, Men and women
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-176834DOI: 10.1016/j.biopsycho.2012.03.003ISI: 000304508700004OAI: oai:DiVA.org:uu-176834DiVA: diva2:537337
Available from: 2012-06-26 Created: 2012-06-26 Last updated: 2012-06-26Bibliographically approved

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