uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prevention of hypertension and organ damage in 2-kidney, 1-clip rats by tetradecylthioacetic acid.
Show others and affiliations
2006 (English)In: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 48, no 3, 460-6 p.Article in journal (Refereed) Published
Abstract [en]

Dietary lipids are reported to affect the blood pressure in both humans and experimental animal models with hypertension. In the present study, 2-kidney, 1-clip (2K1C) hypertensive rats were treated with the modified fatty acid tetradecylthioacetic acid (TTA) from the time of clipping or after hypertension was established. TTA treatment attenuated the development of hypertension and reduced established 2K1C hypertension. The mRNA level of renin in the clipped kidney and the plasma renin activity were markedly reduced, and the plasma angiotensin II level tended to decrease after TTA treatment. In addition, TTA reduced the mRNA level of angiotensinogen in white adipose tissue. Prevention of organ damage was demonstrated by normal urinary excretion of protein, maintained serum albumin, lower heart weight, and clearly reduced vascular, glomerular, and tubulointerstitial damage in the nonclipped kidney. Renal function was not affected as estimated by unchanged plasma creatinine. Furthermore, the serum levels of triacylglycerol and cholesterol were reduced by TTA. The serum fatty acid composition was changed, resulting in a favorable increase of oleic acid. However, the levels of all of the omega-3 fatty acids and of linoleic acid were reduced, and no change was seen in the level of arachidonic acid, but the urinary excretion of 8-iso-prostaglandin F2alpha was declined. In conclusion, TTA attenuated the development of hypertension, reduced established hypertension, and prevented the development of organ damage in 2K1C rats, possibly by reducing the amounts of the vasoconstrictors angiotensin II and 8-iso-prostaglandin F2alpha and by inducing a favorable increase of oleic acid in serum.

Place, publisher, year, edition, pages
2006. Vol. 48, no 3, 460-6 p.
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-170526DOI: 10.1161/01.HYP.0000233018.60736.70PubMedID: 16847149OAI: oai:DiVA.org:uu-170526DiVA: diva2:538954
Available from: 2012-07-02 Created: 2012-03-12 Last updated: 2017-12-07
In thesis
1. Angiotensin II in hypertension, renal damage and renal vascular function
Open this publication in new window or tab >>Angiotensin II in hypertension, renal damage and renal vascular function
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Bergen: Universitetet i Bergen, 2010
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-177054 (URN)9788230815670 (ISBN)
Public defence
2010-08-27, Bergen, 10:00 (English)
Opponent
Supervisors
Available from: 2012-07-09 Created: 2012-07-02 Last updated: 2017-02-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
Hypertension
Physiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 396 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf