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Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2012 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 35, no 2, 160-165 p.Article in journal (Refereed) Published
Abstract [en]

This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/mu l, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 35, no 2, 160-165 p.
Keyword [en]
Ghrelin, Tail suspension test, Olfactory bulbectomy, Hyperactivity, Antidepressant
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-177248DOI: 10.1016/j.peptides.2012.03.031ISI: 000304895500003OAI: oai:DiVA.org:uu-177248DiVA: diva2:539628
Available from: 2012-07-04 Created: 2012-07-04 Last updated: 2013-01-07Bibliographically approved

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Schiöth, Helgi B.
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