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Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2003 (English)In: Toxicol Appl Pharmacol, ISSN 0041-008X, Vol. 193, no 2, 168-76 p.Article in journal (Other scientific) Published
Place, publisher, year, edition, pages
2003. Vol. 193, no 2, 168-76 p.
Keyword [en]
Abnormalities; Drug-Induced, Administration; Oral, Animals, Arrhythmia/*chemically induced/embryology, Cation Transport Proteins, Dose-Response Relationship; Drug, Ether-A-Go-Go Potassium Channels, Female, Fetal Hypoxia/chemically induced/physiopathology, Image Processing; Computer-Assisted, Injections; Intravenous, Nitroimidazoles/administration & dosage/diagnostic use, Potassium Channel Blockers/administration & dosage/*toxicity, Potassium Channels/*drug effects/metabolism, Potassium Channels; Voltage-Gated, Pregnancy, Propanolamines/administration & dosage/*toxicity, Rats, Rats; Sprague-Dawley, Teratogens/*toxicity, Videotape Recording
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URN: urn:nbn:se:uu:diva-26189PubMedID: 14644619OAI: oai:DiVA.org:uu-26189DiVA: diva2:53963
Available from: 2007-02-15 Created: 2007-02-15 Last updated: 2011-01-13

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Danielsson, Bengt R

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