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Distribution of P75 neurotrophin receptor in adult human cochlea: an immunohistochemical study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2012 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 348, no 3, 407-415 p.Article in journal (Refereed) Published
Abstract [en]

Mechanisms underlying the unique survival property of human spiral neurons are yet to be explored. P75 (p75(NTR)) is a low affinity receptor for neurotrophins and is known to interact with Trk receptors to modulate ligand binding and signaling. Up-regulation of this receptor was found to be associated with apoptosis as well as with cell proliferation. Its distribution and injury-induced change in expression pattern in the cochlea have been mainly studied in rodents. There is still no report concerning p75(NTR) in post-natal human inner ear. We analyzed, for the first time, p75(NTR) expression in five freshly fixed human cochleae by using immunohistochemistry techniques, including myelin basic protein (MBP) as a myelin sheath marker and TrkB as the human spiral neuron marker, and by using thin optical sectioning of laser confocal microscopy. The inner ear specimens were obtained from adult patients who had normal pure tone thresholds before the surgical procedures, via a trans-cochlear approach for removal of giant posterior cranial fossa meningioma. The expression of p75(NTR) was investigated and localized in the glial cells, including Schwann cells and satellite glial cells in the Rosenthal canal, in the central nerve bundles within the modiolus, and in the osseous spiral lamina of the human cochleae. The biological significance of p75(NTR) in human cochlea is discussed.

Place, publisher, year, edition, pages
2012. Vol. 348, no 3, 407-415 p.
Keyword [en]
p75(NTR), Cochlea, Glial cells, Neurotrophin receptor, Spiral ganglion, Human
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-177228DOI: 10.1007/s00441-012-1395-7ISI: 000304814500004OAI: oai:DiVA.org:uu-177228DiVA: diva2:540528
Available from: 2012-07-10 Created: 2012-07-04 Last updated: 2017-12-07Bibliographically approved

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Liu, WeiKinnefors, AndersRask-Andersen, Helge

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