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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2012 (English)In: Alcohol, ISSN 0741-8329, E-ISSN 1873-6823, Vol. 46, no 4, 359-370 p.Article in journal (Refereed) Published
Abstract [en]

This review represents the focus of a symposium that was presented at the "Alcoholism and Stress: A Framework for Future Treatment Strategies" conference in Volterra, Italy on May 3-6, 2011 and organized/chaired by Dr. Brendan M. Walker. The primary goal of the symposium was to evaluate and disseminate contemporary findings regarding the emerging role of kappa-opioid receptors (KORs) and their endogenous ligands dynorphins (DYNs) in the regulation of,escalated alcohol consumption, negative affect and cognitive dysfunction associated with alcohol dependence, as well as DYN/KOR mediation of the effects of chronic stress on alcohol reward and seeking behaviors. Dr. Glenn Valdez described a role for KORs in the anxiogenic effects of alcohol withdrawal. Dr. Jay McLaughlin focused on the role of KORs in repeated stress-induced potentiation of alcohol reward and increased alcohol consumption. Dr. Brendan Walker presented data characterizing the effects of KOR antagonism within the extended amygdala on withdrawal-induced escalation of alcohol self-administration in dependent animals. Dr. Georgy Bakalkin concluded with data indicative of altered DYNs and KORs in the prefrontal cortex of alcohol dependent humans that could underlie diminished cognitive performance. Collectively, the data presented within this symposium identified the multifaceted contribution of KORs to the characteristics of acute and chronic alcohol-induced behavioral dysregulation and provided a foundation for the development of pharmacotherapeutic strategies to treat certain aspects of alcohol use disorders.

Place, publisher, year, edition, pages
2012. Vol. 46, no 4, 359-370 p.
Keyword [en]
Alcohol, Anxiety, Central nucleus of the amygdala, Cognitive dysfunction, Decision making, Dependence, Depression, Dynorphin, Extended amygdala, Impulsivity, Kappa opioid receptor, Negative affect, Negative reinforcement, Nor-binaltorphimine (nor-BNI), Nucleus accumbens, Opioid, Orbitofrontal cortex, Prefrontal cortex, Place preference, Self-administration, Stress, Withdrawal
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-177224DOI: 10.1016/j.alcohol.2011.10.006ISI: 000305046800009OAI: oai:DiVA.org:uu-177224DiVA: diva2:540922
Available from: 2012-07-12 Created: 2012-07-04 Last updated: 2012-07-12Bibliographically approved

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