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Regulation of EMT by TGFβ in cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2012 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 586, no 14, 1959-1970 p.Article, review/survey (Refereed) Published
Abstract [en]

Transforming growth factor-beta (TGF beta) suppresses tumor formation since it inhibits cell growth and promotes apoptosis. However, in advanced cancers TGF beta elicits tumor promoting effects through its ability to induce epithelial-mesenchymal transition (EMT) which enhances invasiveness and metastasis; in addition, TGF beta exerts tumor promoting effects on non-malignant cells of the tumor, including suppression of immune surveillance and stimulation of angiogenesis. TGF beta promotes EMT by transcriptional and posttranscriptional regulation of a group of transcription factors that suppresses epithelial features, such as expression of components of cell junctions and polarity complexes, and enhances mesenchymal features, such as production of matrix molecules and several cytokines and growth factors that stimulate cell migration. The EMT program has certain similarities with the stem cell program. Inducers and effectors of EMT are interesting targets for the development of improved diagnosis, prognosis and therapy of cancer. 

Place, publisher, year, edition, pages
2012. Vol. 586, no 14, 1959-1970 p.
Keyword [en]
Cancer stem cell, Epithelial-mesenchymal transition, MAPK, Metastasis, Smad, TGF beta
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-177887DOI: 10.1016/j.febslet.2012.02.037ISI: 000305756300015PubMedID: 22710176OAI: oai:DiVA.org:uu-177887DiVA: diva2:541628
Available from: 2012-07-20 Created: 2012-07-20 Last updated: 2017-12-07Bibliographically approved

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Heldin, Carl-HenrikVanlandewijck, MichaelMoustakas, Aristidis

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Ludwig Institute for Cancer ResearchDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
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