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Solubility of Fractal Nanoparticles
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)ORCID iD: 0000-0002-5496-9664
2007 (English)In: Surface Science, ISSN 0039-6028, E-ISSN 1879-2758, Vol. 601, no 2, 315-319 p.Article in journal (Refereed) Published
Abstract [en]

A relationship between the fractal surface dimension of dissolving nanoparticles and their solubility has been derived showing that fractally rough nanoparticles are expected to exhibit significantly higher solubility than predicted from the classical Ostwald–Freundlich equation. The derived relationship estimates the latent solubility increase for a given material by manipulating the surface of the particles to be dissolved, and can thus be used for developing new strategies for improving the solubility of poorly soluble drug candidates.

Place, publisher, year, edition, pages
2007. Vol. 601, no 2, 315-319 p.
Keyword [en]
Fractal surface dimension, Dissolution, Solubility, Nanoparticles, Ostwald–Freundlich equation
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-26487DOI: 10.1016/j.susc.2006.09.037ISI: 000244006200004OAI: oai:DiVA.org:uu-26487DiVA: diva2:54261
Available from: 2007-09-24 Created: 2007-09-24 Last updated: 2017-12-07Bibliographically approved

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Mihranyan, AlbertStrömme, Maria

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