Solubility of Fractal Nanoparticles
2007 (English)In: Surface Science, ISSN 0039-6028, E-ISSN 1879-2758, Vol. 601, no 2, 315-319 p.Article in journal (Refereed) Published
A relationship between the fractal surface dimension of dissolving nanoparticles and their solubility has been derived showing that fractally rough nanoparticles are expected to exhibit significantly higher solubility than predicted from the classical Ostwald–Freundlich equation. The derived relationship estimates the latent solubility increase for a given material by manipulating the surface of the particles to be dissolved, and can thus be used for developing new strategies for improving the solubility of poorly soluble drug candidates.
Place, publisher, year, edition, pages
2007. Vol. 601, no 2, 315-319 p.
Fractal surface dimension, Dissolution, Solubility, Nanoparticles, Ostwald–Freundlich equation
Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-26487DOI: 10.1016/j.susc.2006.09.037ISI: 000244006200004OAI: oai:DiVA.org:uu-26487DiVA: diva2:54261