uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: Association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance
Show others and affiliations
2012 (English)In: Molecular Nutrition & Food Research, ISSN 1613-4125, E-ISSN 1613-4133, Vol. 56, no 2, 309-315 p.Article in journal (Refereed) Published
Abstract [en]

Scope: Several insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes. To examine whether the genetic variability at the IRS-2 gene locus was associated with the degree of insulin resistance and plasma fatty acid levels in metabolic syndrome (MetS) subjects.

Methods and results: Insulin sensitivity, insulin secretion, glucose effectiveness, plasma fatty acid composition and three IRS-2 tag-single nucleotide polymorphisms (SNPs) were determined in 452 MetS subjects. Among subjects with the lowest level of monounsaturated (MUFA) (below the median), the rs2289046 A/A genotype was associated with lower glucose effectiveness (p < 0.038), higher fasting insulin concentrations (p < 0.028) and higher HOMA IR (p < 0.038) as compared to subjects carrying the minor G-allele (A/G and G/G). In contrast, among subjects with the highest level of MUFA (above the median), the A/A genotype was associated with lower fasting insulin concentrations and HOMA-IR, whereas individuals carrying the G allele and with the highest level of omega-3 polyunsaturated fatty acids (above the median) showed lower fasting insulin (p < 0.01) and HOMA-IR (p < 0.02) as compared with A/A subjects.

Conclusion: The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in MetS subjects.

Place, publisher, year, edition, pages
2012. Vol. 56, no 2, 309-315 p.
Keyword [en]
Fatty acids, Metabolic syndrome, Nutrigenomics, n-3 PUFA, Polymorphism
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-178939DOI: 10.1002/mnfr.201100504ISI: 000305065900012OAI: oai:DiVA.org:uu-178939DiVA: diva2:542836
Available from: 2012-08-03 Created: 2012-08-02 Last updated: 2012-08-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Karlström, Brita
By organisation
Clinical Nutrition and Metabolism
In the same journal
Molecular Nutrition & Food Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 139 hits
ReferencesLink to record
Permanent link

Direct link