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Influence of smoking and snuff cessation on risk of preterm birth
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
2012 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 27, no 4, 297-304 p.Article in journal (Refereed) Published
Abstract [en]

The mechanisms by which antenatal smoking exposure increases the risk of preterm birth remain unknown. Swedish oral moist snuff contains quantities of nicotine comparable to those typically absorbed from cigarette smoking, but does not result in exposure to the products of combustion, for example carbon monoxide. In a nationwide study of 776,836 live singleton births in Sweden from 1999 to 2009, the authors used multiple logistic regression models to examine associations between cessation of smoking and Swedish snuff use early in pregnancy and risk of preterm birth (before 37 weeks). Compared with nontobacco users both before and in early pregnancy, the adjusted odds ratios (OR), 95 % confidence interval (CI) were OR = 0.92, 95 % CI 0.84-1.01, for women who stopped using snuff, and OR = 0.90, 95 % CI 0.87-0.94, for women who stopped smoking. In contrast, continued snuff use and smoking were associated with increased risks of preterm birth (adjusted OR = 1.29, 95 % CI 1.17-1.43, adjusted OR = 1.30, 95 % CI 1.25-1.36, respectively). The snuff and smoking-related risks were, if anything, higher for very (before 32 weeks) than moderately (32-36 weeks) preterm birth, and also higher for spontaneous than induced pretermbirth. These findings suggest that antenatal exposure to nicotine is involved in the mechanism by which tobacco use increase the risk of preterm birth.

Place, publisher, year, edition, pages
2012. Vol. 27, no 4, 297-304 p.
Keyword [en]
Snuff, Smoking, Reduction, Preterm birth, Cessation of tobacco
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-178919DOI: 10.1007/s10654-012-9676-8ISI: 000305219300006OAI: oai:DiVA.org:uu-178919DiVA: diva2:542847
Available from: 2012-08-03 Created: 2012-08-02 Last updated: 2012-08-03Bibliographically approved

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Wikström, Anna-Karin
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