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Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2012 (English)In: Current opinion in pharmacology (Print), ISSN 1471-4892, E-ISSN 1471-4973, Vol. 12, no 3, 340-346 p.Article in journal (Refereed) Published
Abstract [en]

The neuromuscular junction (NMJ) is a specialized synapse between motor neurons and skeletal muscle with a complex signaling network that assures highly reliable neuromuscular transmission. Diseases of the NMJ cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Moreover, fragmentation of the NMJ contributes to sarcopenia, the loss of muscle mass during aging. Studies from recent years indicate that the formation and stabilization of NMJs differs between various muscles and that this difference affects their response under pathological conditions. This review summarizes the most important mechanisms involved in the development, maintenance and dysfunction of the NMJ and it discusses their significance in myasthenic disorders and aging and as targets for possible future treatment of NMJ dysfunction.

Place, publisher, year, edition, pages
2012. Vol. 12, no 3, 340-346 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-179041DOI: 10.1016/j.coph.2012.02.002ISI: 000306160600017OAI: oai:DiVA.org:uu-179041DiVA: diva2:543028
Available from: 2012-08-06 Created: 2012-08-06 Last updated: 2012-08-06Bibliographically approved

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