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Patterns of metastasis in women with metachronous contralateral breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
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2012 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 107, no 2, 221-223 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.

METHODS: A cohort of 8478 women with breast cancer treated at Guy's and St Thomas' NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.

RESULTS: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.

CONCLUSION: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.

Place, publisher, year, edition, pages
2012. Vol. 107, no 2, 221-223 p.
Keyword [en]
metachronous cancer, contralateral breast cancer, patterns of metastasis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-179019DOI: 10.1038/bjc.2012.273ISI: 000306324600001PubMedID: 22735901OAI: oai:DiVA.org:uu-179019DiVA: diva2:543106
Available from: 2012-08-06 Created: 2012-08-06 Last updated: 2013-02-08Bibliographically approved

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Garmo, HansHolmberg, Lars
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