Patterns of metastasis in women with metachronous contralateral breast cancer
2012 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 107, no 2, 221-223 p.Article in journal (Refereed) Published
BACKGROUND: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.
METHODS: A cohort of 8478 women with breast cancer treated at Guy's and St Thomas' NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.
RESULTS: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.
CONCLUSION: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.
Place, publisher, year, edition, pages
2012. Vol. 107, no 2, 221-223 p.
metachronous cancer, contralateral breast cancer, patterns of metastasis
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-179019DOI: 10.1038/bjc.2012.273ISI: 000306324600001PubMedID: 22735901OAI: oai:DiVA.org:uu-179019DiVA: diva2:543106