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Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear
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2012 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 132, no 8, 807-813 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: It is suggested that aquaporins (AQPs) 1, 2, and 3, and vasopressin type 2 receptors (V2Rs) in the fluid transporting cells, such as stria vascularis, vestibular dark and transitional cells, and endolymphatic sac epithelial cells, have an important role in fluid transport in the inner ear, while those in the sensory and ganglion cells may play a functional role in the sensory cell transduction system.

Objective: To analyze expression of AQP1, AQP2, and AQP3 as well as V2Rs in the normal mouse inner ear.

Methods: CBA/J mice were used in this study. Localization of AQP1, AQP2, AQP3, and V2Rs in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry.

Results: The results show that AQP1, AQP2, AQP3, and V2Rs are abundantly distributed in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac.

Place, publisher, year, edition, pages
2012. Vol. 132, no 8, 807-813 p.
Keyword [en]
Immunohistochemistry, fluid transport, sensory cell transduction
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-179553DOI: 10.3109/00016489.2012.662718ISI: 000306652800003OAI: oai:DiVA.org:uu-179553DiVA: diva2:545457
Available from: 2012-08-20 Created: 2012-08-20 Last updated: 2012-08-20Bibliographically approved

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Anniko, Matti
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Otolaryngology and Head and Neck Surgery
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