uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Clinical aspects of using exhaled NO in asthma diagnosis and management
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Show others and affiliations
2012 (English)In: Clinical Respiratory Journal, ISSN 1752-6981, Vol. 6, no 4, 193-207 p.Article, review/survey (Refereed) Published
Abstract [en]


Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO ) is a simple, non-invasive and cost-effective online test, applicable in both adults and children. In addition to symptoms and lung function measurements, FENO reflects airway eosinophilia and hence allows online assessment of the corticosteroid-sensitive Th2-type airway inflammation in asthmatic patients. FENO can thus be applied to aid asthma diagnosis and treatment monitoring both in clinical practice and for research purposes.


The scope of this review is to provide an overview of the most important clinical studies using FENO in asthma management and to summarise the implications of FENO measurements in clinical practice.

Results and conclusion

In several studies, FENO measurements provided additional information on aspects of asthma including phenotyping, corticosteroid-responsiveness and disease control. Thus, if correctly applied and interpreted, FENO can aid asthma diagnosis, choice of treatment and to identify patients at risk of exacerbation. A simple and reliable tool to quantify peripheral NO will further aid to identify patients with small airways inflammation.

Place, publisher, year, edition, pages
2012. Vol. 6, no 4, 193-207 p.
Keyword [en]
airway inflammation, asthma, asthma diagnosis, asthma management, asthma phenotypes, exhaled nitric oxide
National Category
Respiratory Medicine and Allergy
URN: urn:nbn:se:uu:diva-179788DOI: 10.1111/crj.12001ISI: 000308641100001OAI: oai:DiVA.org:uu-179788DiVA: diva2:546252
Available from: 2012-08-22 Created: 2012-08-22 Last updated: 2012-10-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Alving, KjellMalinovschi, Andrei
By organisation
PediatricsClinical Physiology
In the same journal
Clinical Respiratory Journal
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 188 hits
ReferencesLink to record
Permanent link

Direct link