Clinical aspects of using exhaled NO in asthma diagnosis and management
2012 (English)In: Clinical Respiratory Journal, ISSN 1752-6981, Vol. 6, no 4, 193-207 p.Article, review/survey (Refereed) Published
Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO ) is a simple, non-invasive and cost-effective online test, applicable in both adults and children. In addition to symptoms and lung function measurements, FENO reflects airway eosinophilia and hence allows online assessment of the corticosteroid-sensitive Th2-type airway inflammation in asthmatic patients. FENO can thus be applied to aid asthma diagnosis and treatment monitoring both in clinical practice and for research purposes.
The scope of this review is to provide an overview of the most important clinical studies using FENO in asthma management and to summarise the implications of FENO measurements in clinical practice.
Results and conclusion
In several studies, FENO measurements provided additional information on aspects of asthma including phenotyping, corticosteroid-responsiveness and disease control. Thus, if correctly applied and interpreted, FENO can aid asthma diagnosis, choice of treatment and to identify patients at risk of exacerbation. A simple and reliable tool to quantify peripheral NO will further aid to identify patients with small airways inflammation.
Place, publisher, year, edition, pages
2012. Vol. 6, no 4, 193-207 p.
airway inflammation, asthma, asthma diagnosis, asthma management, asthma phenotypes, exhaled nitric oxide
Respiratory Medicine and Allergy
IdentifiersURN: urn:nbn:se:uu:diva-179788DOI: 10.1111/crj.12001ISI: 000308641100001OAI: oai:DiVA.org:uu-179788DiVA: diva2:546252