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Mortality prediction in the elderly by an easily measured metabolic index
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
2012 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, Vol. 9, no 3, 226-233 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Hyperglycaemia enhances the risk of cardiovascular events and death, while high-density lipoprotein cholesterol (HDLc) is protective. Information on these associations among the elderly population is scanty. We applied a cardiometabolic risk index (CMRI) based on HDLc and fasting plasma glucose (FPG) in an elderly Swedish population.

Methods: In total, 432 75-year-olds were followed for 10-year mortality. The impact of risk factors on survival was analysed using Cox regression.

Results: HDLc (mmol/1; median and interquartile range) was 1.6 (1.3-2.0) in women and 1.4 (1.2-1.5) in men, while FPG was 5.9 (5.5-6.6) and 5.9 (5.5-6.5). Some 89 persons were at high risk according to CMRI, and 163 persons died. FPG was related to mortality in women (HR: 95% CI: 1.23; 1.10-1.37) and there was a similar trend in men (1.08; 1.00-1.17; p = 0.061). Increasing HDLc was protective in men (0.38; 0.19-0.77) but not in women (0.77; 0.45-1.29). CMRI was related to mortality in both genders even after adjustment for established risk factors (1.79; 1.14-2.79; p = 0.011).

Conclusions: The CMRI helps identify elderly subjects at risk and may serve as a cost-effective risk prediction tool.

Place, publisher, year, edition, pages
2012. Vol. 9, no 3, 226-233 p.
Keyword [en]
Cardiometabolic risk, elderly, fasting glucose, gender, HDL cholesterol, survival
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-179930DOI: 10.1177/1479164111434317ISI: 000306940800008OAI: oai:DiVA.org:uu-179930DiVA: diva2:547161
Available from: 2012-08-27 Created: 2012-08-27 Last updated: 2012-08-27Bibliographically approved

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Nilsson, Göran
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