Mortality prediction in the elderly by an easily measured metabolic index
2012 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, Vol. 9, no 3, 226-233 p.Article in journal (Refereed) Published
Objective: Hyperglycaemia enhances the risk of cardiovascular events and death, while high-density lipoprotein cholesterol (HDLc) is protective. Information on these associations among the elderly population is scanty. We applied a cardiometabolic risk index (CMRI) based on HDLc and fasting plasma glucose (FPG) in an elderly Swedish population.
Methods: In total, 432 75-year-olds were followed for 10-year mortality. The impact of risk factors on survival was analysed using Cox regression.
Results: HDLc (mmol/1; median and interquartile range) was 1.6 (1.3-2.0) in women and 1.4 (1.2-1.5) in men, while FPG was 5.9 (5.5-6.6) and 5.9 (5.5-6.5). Some 89 persons were at high risk according to CMRI, and 163 persons died. FPG was related to mortality in women (HR: 95% CI: 1.23; 1.10-1.37) and there was a similar trend in men (1.08; 1.00-1.17; p = 0.061). Increasing HDLc was protective in men (0.38; 0.19-0.77) but not in women (0.77; 0.45-1.29). CMRI was related to mortality in both genders even after adjustment for established risk factors (1.79; 1.14-2.79; p = 0.011).
Conclusions: The CMRI helps identify elderly subjects at risk and may serve as a cost-effective risk prediction tool.
Place, publisher, year, edition, pages
2012. Vol. 9, no 3, 226-233 p.
Cardiometabolic risk, elderly, fasting glucose, gender, HDL cholesterol, survival
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-179930DOI: 10.1177/1479164111434317ISI: 000306940800008OAI: oai:DiVA.org:uu-179930DiVA: diva2:547161