Novel Trisubstituted Harmine Derivatives with Original in Vitro Anticancer Activity
2012 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 55, no 14, 6489-6501 p.Article in journal (Refereed) Published
To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel beta-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor. Of the synthesized compounds, the most active in terms of growth inhibition of five cancer cell lines are cytostatic and approximately 100 times more potent than harmine but demonstrated no DYRK1A inhibitory activity. These novel beta-carbolines display similar growth inhibitory activity in cancer cells that are sensitive and resistant to apoptotic stimuli. Using ChemGPS-NP, we found that the more active beta-carbolines are all more lipophilic and larger than the less active compounds. Lastly, on the basis of the NCI human tumor cell line anticancer drug screen and the NCI COMPARE algorithm, it appears that some of these compounds, including 5a and 5k, seem to act as protein synthesis inhibitors.
Place, publisher, year, edition, pages
2012. Vol. 55, no 14, 6489-6501 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-179917DOI: 10.1021/jm300542eISI: 000306764600022OAI: oai:DiVA.org:uu-179917DiVA: diva2:547199