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Incorporation of active ions into calcium phosphate coatings, their release behavior and mechanism
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Dept of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
2012 (English)In: Biomedical Materials, ISSN 1748-6041, E-ISSN 1748-605X, Vol. 7, no 4, 045018- p.Article in journal (Refereed) Published
Abstract [en]

The dissolution and release of active ions from ion-doped apatites is currently gaining interest due to indications of a beneficial biologic response. The release of ions from apatite coatings is important because it influences the biological effect of these types of materials. In this study the ion release from three different ion-doped apatite coatings (iHA coatings), SrCaP, SiHA and FHA, has been studied. The coatings were prepared by a mineralization method based on immersion in modified PBS solutions containing additions of Sr, Si or F. The kinetics of ion release from the iHA coatings were studied in two different media with and without calcium and phosphate ions (phosphate buffer saline solution (PBS) and Tris-HCl). The amount of cumulative release of Sr, Si and F ions from the iHA coatings was SrCaP > SiHA > FHA in Tris-HCl, which could be also be related to the solubility for these iHA coatings. According to analysis using the Korsmeyer-Peppas model, the release of ions from the coatings was in most cases controlled by a combination of Fickian diffusion and dissolution of the coatings. The morphologies of the iHA coatings were not markedly changed after immersion in Tris-HCl. In the phosphate buffer solution, there was a concurrent redeposition of new apatite crystals on the surface of all of the iHA coatings, which means there were both a dissolution and a remineralization process acting, ultimately controlling the ion release rate.

Place, publisher, year, edition, pages
2012. Vol. 7, no 4, 045018- p.
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-179905DOI: 10.1088/1748-6041/7/4/045018ISI: 000306712900018OAI: oai:DiVA.org:uu-179905DiVA: diva2:547483
Available from: 2012-08-28 Created: 2012-08-27 Last updated: 2017-12-07Bibliographically approved
In thesis
1. Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
Open this publication in new window or tab >>Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The clinical success of a bone-anchored implant is controlled by many factors such as implant shape, chemical composition, mechanical and surface properties. The surface properties (e.g. charge, wettability and roughness) are considered to be important parameters for the biological acceptance of the biomaterial, whereas the bulk properties control the biomechanical behaviour. For implants designed to be used in load-bearing applications in the skeletal system, the biomaterial should preferably integrate into bone tissue for a long lasting function. Lack of integration between the implant and bone increases the risk of micromotions, infections, soft tissue encapsulation, which all reduces the survival rate of the implant and makes revision surgery necessary. Coatings and surface modifications can be used to tailor properties of implant surfaces, and further improve the potential bone bonding and bone in-growth, compared to unmodified surfaces. A biomimetic method, developed by Kokubo, can be used to prepare a hydroxyapatite coating on to titanium substrates. The method is based on a solution based process where the compositions of the soaking medium and thus the formed coatings can be controlled. In this thesis, titanium (oxide) surfaces have been tailored via deposition of ion substituted hydroxyapatite coatings. Biologically relevant ions like strontium, silicon and fluoride were incorporated into apatite coatings. The substrates included well-defined rutile single crystals, as well as poly-crystalline titanium oxide surfaces and experimental Ti implants. The results showed that incorporation of substitute ions alters the morphology, crystallinity, composition and dissolution rates of apatite coatings. The in vivo effects of the ion substituted apatite coatings were also studied. The results showed that the ion substituted apatite coatings have good biocompatibility and can promote early bone formation.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 57 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 986
National Category
Bio Materials
Research subject
Materials Science
Identifiers
urn:nbn:se:uu:diva-183345 (URN)978-91-554-8510-8 (ISBN)
Public defence
2012-12-06, Polacksbacken 2146, Ångströmslaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (Swedish)
Opponent
Supervisors
Available from: 2012-11-16 Created: 2012-10-24 Last updated: 2013-01-23Bibliographically approved

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Lindahl, CarlXia, WeiEngqvist, Håkan

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