The effect of local gentamicin-collagen on perineal wound complications and cancer recurrence after abdominoperineal resection: a multicentre randomised controlled trial
2013 (English)In: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318, Vol. 15, no 3, 341-346 p.Article in journal (Refereed) Published
Perineal wound sepsis is a common problem after abdominoperineal resection of the rectum (APR), with an reported incidence of 10-15% in previously non-radiated patients, 20-30% in patients given preoperative radiation, and 50% among patients submitted to preoperative radiation combined with chemotherapy. The local application of gentamicin-collagen was evaluated to determine whether its use in the perineal wound reduced the risk complications and had an effect on cancer recurrence.
In this prospective multicentre (7 hospitals) randomised controlled trial, 102 patients undergoing APR due to cancer or benign disease were randomised into two groups including surgery with gentamicin-collagen (GS+ n=52), or surgery without gentamicin-collagen (GS- n=50), Patients were followed at 7, 30 and 90 days and at one and five years.
There were no statistically significant differences between the two groups regarding perineal wound complications, infectious or non-infectious or cancer recurrence.
There was no statistically significant effect on perineal wound complications or cancer recurrence following the local administration of gentamicin-collagen during APR.
Place, publisher, year, edition, pages
2013. Vol. 15, no 3, 341-346 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-180098DOI: 10.1111/j.1463-1318.2012.03196.xISI: 000315519300023PubMedID: 22889358OAI: oai:DiVA.org:uu-180098DiVA: diva2:548063