Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes
2012 (English)In: Translational Psychiatry, ISSN 2158-3188, Vol. 2, e76Article in journal (Refereed) Published
Fear memory persistence, central for the development and maintenance of anxiety disorders, is partially genetically controlled. Recently, consolidation and reconsolidation processes have been reported to affect fear memory stability and integrity. This study explored the impact of reconsolidation processes and genetic make-up on fear reacquisition by manipulating reconsolidation using extinction performed outside or inside a reconsolidation interval. Reacquisition measured by skin conductance responses was stronger in individuals that extinguished outside (6 h) than inside (10 min) the reconsolidation interval. However, the effect was predominantly present in val/val homozygotes of the functional val158met polymorphism of the Catechol O-methyltransferase (COMT) enzyme and in short allele carriers of the serotonin transporter length 5-HTTLPR polymorphism. These results demonstrate that reconsolidation of human fear memory is influenced by dopamine and serotonin related genes.
Place, publisher, year, edition, pages
Macmillan Publishers Ltd., 2012. Vol. 2, e76
dopamine, fear conditioning, genes, memory reconsolidation, polymorphism, serotonin
IdentifiersURN: urn:nbn:se:uu:diva-180177DOI: 10.1038/tp.2012.5ISI: 000315989800001PubMedID: 22832813OAI: oai:DiVA.org:uu-180177DiVA: diva2:548747
FunderSwedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare