Serotonergic and dopaminergic modulation of the prevention of return of fear using reconsolidation.
(English)Manuscript (preprint) (Other academic)
Disruption of fear reconsolidation results in permanent memory suppression in fear conditioning protocols in animals and humans. Serotonergic and dopaminergic polymorphisms have been associated to this process. Specifically, reacquisition of fear after disrupted reconsolidation was compromised in human short alle carriers of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and in val/val homozygotes of the val158met catechol-O-methyltransferease (COMT) functional polymorphisms. The present study examined if the gene effects similarly would impact reinstatement, another measure reflecting return of fear, following unpaired shock presentations. Skin conductance responses served as the measure of acquisition, extinction and return of fear. During the reinstatement session return of fear tended to be stronger in in val/val homozygotes of the COMT polymorphism who extinguished outside (6 h) as compared to inside (10 min) the reconsolidation interval following a memory reminder. Carriers of the short allele of the 5-HTTLPR polymorphism displayed a similar pattern in response to the previously shock associated cue. These results partially replicate for reinstatement the gene effect demonstrated previously for reacquisition, but fail to conceptually replicate the main effect averaged over all genotypes. Collectively, data support that reconsolidation of human fear memory is influenced by dopaminergic and serotonergic genes.
Memory reconsolidation; fear conditioning; cold pressor test; serotonin; dopamine; polymorphism; genes
IdentifiersURN: urn:nbn:se:uu:diva-180200OAI: oai:DiVA.org:uu-180200DiVA: diva2:548751
FunderSwedish Research CouncilFAS, Swedish Council for Working Life and Social Research