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Streptozotocin-diabetes in the Chinese hamster. Blood glucose and structural changes during the first 24 hours
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: Hormone and Metabolic Research, ISSN 0018-5043, E-ISSN 1439-4286, Vol. 4, no 6, 426-433 p.Article in journal (Refereed) Published
Abstract [en]

Intraperitoneal administration of 200 mg/kg body weight of streptozotocin to non-diabetic adult Chinese hamsters, evoked a triphasic blood glucose response. There was a hyperglycemic peak after 3 hours and a hypoglycemic phase with a minimum at 6 hours, after which time there was a rather rapid return to hyperglycemia. Light and electron microscopic examinations during the first 24 hours after the injection of streptozotocin showed pyknosis, vacuolization, marked degeneration and necrosis of the β-cells. Degenerative and necrotic changes were also seen in a few α2-cells. The results denote that in the Chinese hamster streptozotocin has an early and direct cytotoxic action on the β-cells and probably also on a few α2-cells.

Place, publisher, year, edition, pages
1972. Vol. 4, no 6, 426-433 p.
Keyword [en]
Chinese Hamster, Streptozotocin, Pancreatic Islets, β-Cell Degeneration, α2-Cell Degeneration, Hyperglycemia
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-180770DOI: 10.1055/s-0028-1094000ISI: A1972O420800005PubMedID: 4120450OAI: oai:DiVA.org:uu-180770DiVA: diva2:551175
Available from: 2012-09-10 Created: 2012-09-10 Last updated: 2012-09-10Bibliographically approved

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