Twenty-five patients (mean age 61+2, range 39-72 years)with severe chronic obstructive lung disease, with a maximumvoluntary ventilation (MWF), without bronchodilating spray,< 35 % of the individually predicted normal value, were classifiedinto two groups: (1) a group who had suffered from atleast one period of absolute respiratory insufficiency (R), with8 men and 6 women, and (2) a comparison (C) group withthe corresponding degree of MVVF limitation but withoutany period of absolute respiratory insufficiency, with 10 menand 1 woman. The patients were studied in their habitualstate by a standard ergometer-bicycle exercise test. Thehighest performed work load, near maximal (Wmax), wasdetermined, and also the pulmonary gas exchange, arterialblood(0, and CO,) gas tensions, lactate concentration andacid-base balance under the conditions of maximum work load.MVVF and W,,, were found to be positively correlatedin the R and C groups, but not in the female patients. W,,,was also correlated to other factors, namely negatively toresting FRC/TLC and RV/TLC, and to V,/ V, measured undermaximum working conditions. Average W,,, was 189+ 52 inthe male R group and 118+37 kpm/min in the female, andin the male C group 256+40 kpm/min. W,,, in kpm/minper kg body weight was in the R group 2.63+ 0.57 and in theC group 4.29k0.65. There was a tendency to lower PaOIand CaO, during maximum work and higher heart rate in relationto work load in the R group than in the C group althoughthis was not statistically significant.
1972. Vol. 77, no 3, 189-201 p.