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Physical Working Capacity in Severe ChronicObstructive Lung Disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 77, no 3, 189-201 p.Article in journal (Refereed) Published
Abstract [en]

Twenty-five patients (mean age 61+2, range 39-72 years)with severe chronic obstructive lung disease, with a maximumvoluntary ventilation (MWF), without bronchodilating spray,< 35 % of the individually predicted normal value, were classifiedinto two groups: (1) a group who had suffered from atleast one period of absolute respiratory insufficiency (R), with8 men and 6 women, and (2) a comparison (C) group withthe corresponding degree of MVVF limitation but withoutany period of absolute respiratory insufficiency, with 10 menand 1 woman. The patients were studied in their habitualstate by a standard ergometer-bicycle exercise test. Thehighest performed work load, near maximal (Wmax), wasdetermined, and also the pulmonary gas exchange, arterialblood(0, and CO,) gas tensions, lactate concentration andacid-base balance under the conditions of maximum work load.MVVF and W,,, were found to be positively correlatedin the R and C groups, but not in the female patients. W,,,was also correlated to other factors, namely negatively toresting FRC/TLC and RV/TLC, and to V,/ V, measured undermaximum working conditions. Average W,,, was 189+ 52 inthe male R group and 118+37 kpm/min in the female, andin the male C group 256+40 kpm/min. W,,, in kpm/minper kg body weight was in the R group 2.63+ 0.57 and in theC group 4.29k0.65. There was a tendency to lower PaOIand CaO, during maximum work and higher heart rate in relationto work load in the R group than in the C group althoughthis was not statistically significant.

Place, publisher, year, edition, pages
1972. Vol. 77, no 3, 189-201 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-180713ISI: A1972O271900010OAI: oai:DiVA.org:uu-180713DiVA: diva2:551349
Available from: 2012-09-11 Created: 2012-09-10 Last updated: 2012-09-11Bibliographically approved

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