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Influence of Antigenic Stimulation on Lymphoid Cell Traffic in the Chicken: II. Increased Homing of Bone Marrow-Derived Cells to the Bursa of Fabricius after Human Serum Albumin Administration
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: International Archives of Allergy and Applied Immunology, ISSN 0020-5915, Vol. 43, no 6, p. 921-933Article in journal (Refereed) Published
Abstract [en]

6-week-old chickens were immunized with a single intravenous injection of human serum albumin (HSA). 24 h after the immunization, the chickens and nonimmunized saline-injected control chickens were locally labelled in the bone marrow with 3H-thymidíne. 48 h after labelling, the chickens were sacrificed and the distribution of label between different lymphoid organs in the immunized and the nonimmunized chickens was compared with a radiochemical method and with autoradiography. An increased proportion of bone marrow-derived tritium-labelled DNA and significantly more heavily labelled bone marrow-derived cells were found in the bursa of Fabricius of the HSA-immunized chickens as compared with the nonimmunized controls. The heavily labelled bone marrow-derived cells were pyroninophilic, and were located in the follicular cortex, as well as in the medulla. There was no indication of an increase of the normal transport of label or of heavily labelled cells from the bone marrow to other lymphoid organs in the immunized chickens. It is suggested that the increased homing of bone marrow-derived cells to the bursa of Fabricius, 72 h after the antigenic stimulation, may reflect a recruitment of bursa cell precursors.

Place, publisher, year, edition, pages
1972. Vol. 43, no 6, p. 921-933
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-180776DOI: 10.1159/000230909ISI: A1972P179900012OAI: oai:DiVA.org:uu-180776DiVA: diva2:551529
Available from: 2012-09-11 Created: 2012-09-10 Last updated: 2012-09-11Bibliographically approved

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