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Influence of Antigenic Stimulation on Lymphoid Cell Traffic in the Chicken: I. Increased Homing of Thymus-Derived Cells to the Bone Marrow after Antigenic Stimulation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: International Archives of Allergy and Applied Immunology, ISSN 0020-5915, Vol. 43, no 5, 657-670 p.Article in journal (Refereed) Published
Abstract [en]

Six-week-old chickens were either immunized with a single intravenous injection of human serum albumin (HSA) or injected intravenously with physiological saline. 24 h after the HSA or saline administration the chickens were locally labelled in the thymus with 3H-thymidine in vivo. 48 h after the intrathymic labelling the chickens were sacrificed and the influence of the antigenic stimulation on the distribution of label between different lymphoid organs was studied with a radiochemical method based on measurements of tritiated DNA, and with autoradiography. A significantly increased proportion of thymus-derived label was demonstrated with the radiochemical method in the bone marrow of the immunized chickens, as compared to the saline-injected controls. With autoradiography, an increased number of heavily labelled thymus-derived cells were found in the bone marrow of the HSA-immunized chickens. The majority of these cells were small to medium-sized lymphoid cells, but a number of them were large lymphoid cells. None of these cells were plasma cells. There was no apparent increase of thymus-derived label or heavily labelled thymus-derived cells in the spleen or in the cecal tonsils of the immunized chickens. Heavily labelled thymus-derived cells could not be demonstrated in the bursa of Fabricius.

Place, publisher, year, edition, pages
1972. Vol. 43, no 5, 657-670 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-180775DOI: 10.1159/000230882ISI: A1972O859600002OAI: oai:DiVA.org:uu-180775DiVA: diva2:551530
Available from: 2012-09-11 Created: 2012-09-10 Last updated: 2012-09-11Bibliographically approved

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