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A case of massive hypertriglyceridemia corrected by nicotinic acid or nicotinamide therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 16, no 3, 359-368 p.Article in journal (Refereed) Published
Abstract [en]

A case of massive hypertriglyceridemia with fasting plasma triglycerides around 100 mmoles/l is described. Large amounts of chylomicra were present in fasting plasma and the amounts of low-density and high-density lipoproteins were very low. Postheparin plasma lipolytic activity was normal and intravenous heparin rapidly cleared the patient's abnormally prolonged alimentary lipemia with a concomitant rise in plasma free fatty acid levels.

Nicotinic acid or nictotinamide given in doses of 3 g or more daily reduced plasma triglyceride levels to about 2–3 mmoles/1 and raised the reduced levels of low and high-density lipoproteins. The mode of onset of this therapeutic effect was slow and the effect persisted for several weeks after withdrawal of either nicotinic acid or nicotinamide.

The pathogenesis of the hypertriglyceridemia as well as the mode of action of nicotinic acid and nicotinamide is discussed.

Place, publisher, year, edition, pages
1972. Vol. 16, no 3, 359-368 p.
Keyword [en]
Hypertriglyceyidenzia, Nicotinic acid, Nicotinamide, Lipoprotein lipase
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-180753DOI: 10.1016/0021-9150(72)90083-4ISI: A1972O727300006OAI: oai:DiVA.org:uu-180753DiVA: diva2:551728
Available from: 2012-09-12 Created: 2012-09-10 Last updated: 2017-12-07Bibliographically approved

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