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Effect of chlorophenoxyisobutyric acid (CPIB) on fat-mobilizing lipolysis and cyclic AMP levels in rat epididymal fat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 16, no 3, 349-357 p.Article in journal (Refereed) Published
Abstract [en]

High concentrations of chlorophenoxyisobutyric acid (CPIB) reduced basal glycerol release from rat epididymal fat pads in vitro and antagonized the lipolytic effects of noradrenaline. Furthermore, very high concentrations of CPIB significantly antagonized the effects or noradrenaline or ACTH on cyclic AMP accumulation by isolated rat adipocytes. These data are not incompatible with the hypothesis that a primary mechanism in the hypolipidemic action of CPIB is to lower the levels of cyclic AMP in adipose tissue, resulting in decreased hormone-sensitive lipase activity and/or increased lipoprotein lipase activity.

Place, publisher, year, edition, pages
1972. Vol. 16, no 3, 349-357 p.
Keyword [en]
Chlorophenoxyisobutyric acid, Cyclic AMP, CPIB, Fat mobilizing lipolysis, Rat adipose tissue
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-180752DOI: 10.1016/0021-9150(72)90082-2ISI: A1972O727300005OAI: oai:DiVA.org:uu-180752DiVA: diva2:551731
Available from: 2012-09-12 Created: 2012-09-10 Last updated: 2017-12-07Bibliographically approved

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