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Changes in Fertility and Morphology of Sensitized RatUterine Endometrium upon an Intra-uterine Injection of Antigen
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
1972 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 77, no 3, 133-135 p.Article in journal (Refereed) Published
Abstract [en]

Rats were immunized with BCG-vaccine or horse serumand divided into two subgroups, one containing pregnantanimals, the other containing spayed animals treatedwith progesterone. The pregnant rats were given anintra-uterine injection of the antigen on day 3 of preg-MIICY and the number of foetuses was registered. Thespayed rats were fist given progesterone, then an intrauterineinjection of the antigen, and prepared for microscopyat various intervals. The results showed that anintra-uterine injection of BCG-vaccine rendered implantationimpossible and also markedly changed the strnctnreof the endometrium. Serum, in the corresponding experiments,did not block implantation, but morphologicalsigns of an immune reaction were present although notin the uterine epithelium. It is concluded that with thedesign used, an immunological reaction of the immediatetypecanuot change the strnctnre and function of theuterine epithelium sufficiently to render implantation impossible.

Place, publisher, year, edition, pages
1972. Vol. 77, no 3, 133-135 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-180702ISI: A1972O271900001OAI: oai:DiVA.org:uu-180702DiVA: diva2:551862
Available from: 2012-09-12 Created: 2012-09-10 Last updated: 2012-09-12Bibliographically approved

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