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Large transcriptional accuracy variation advocate transcription as a source of amino acid sequence errors
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
(English)Manuscript (preprint) (Other academic)
National Category
Biochemistry and Molecular Biology
Research subject
Biology with specialization in Molecular Biotechnology
Identifiers
URN: urn:nbn:se:uu:diva-181003OAI: oai:DiVA.org:uu-181003DiVA: diva2:552629
Funder
Vinnova
Available from: 2012-09-14 Created: 2012-09-14 Last updated: 2012-10-02
In thesis
1. Exploring and predicting DNA template dependent variation in transcription
Open this publication in new window or tab >>Exploring and predicting DNA template dependent variation in transcription
2012 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Reliable transmission of information from DNA to proteins is a pre-requisite for all life, where substitution errors in the polypeptide chain may arise from transcription, aminoacylation of tRNAs or translation. The fidelity control mechanisms in transcription have nevertheless received little attention, based on the assumption that the transcriptional error is masked by the translational error. This thesis shows how accuracy theory can be applied to transcription to elucidate the principles of transcriptional accuracy. The DNA template dependent transcriptional accuracy variation is studied through modelling based on transition state theory, using thermodynamic properties of the nucleic acids in the transcription bubble. The models show that the error frequency variation in transcription causes it to surpass the translational error in some sequence contexts, making transcription a significant source of amino acids substitution errors.

Place, publisher, year, edition, pages
Uppsala: Uppsala universitet, 2012. 17 p.
Keyword
transcription, accuracy, kinetic proofreading, selection
National Category
Biochemistry and Molecular Biology
Research subject
Biology with specialization in Molecular Biotechnology
Identifiers
urn:nbn:se:uu:diva-181004 (URN)
Presentation
2012-09-28, C8:301, Uppsala Biomedicinska Centrum (BMC), Husarg. 3, Uppsala, 14:52 (English)
Opponent
Supervisors
Funder
Vinnova
Available from: 2012-10-02 Created: 2012-09-14 Last updated: 2012-10-02Bibliographically approved

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CiteExportLink to record
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Output format
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