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The change in the electronic character upon cisplatin binding to guanine nucleotide is transmitted to drive the conformation of the local sugar-phosphate backbone - a quantitative study
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1999 (English)In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, ISSN 0300-922X, no 19, 2835-2843 p.Article in journal (Other scientific) Published
Abstract [en]

The microstructure alteration as a result of cisplatin binding to N7 of guanines in DNA has been herein assessed through the multinuclear temperature-, pH*- and concentration-dependent NMR study of the effect of Pt2+ complexation to 2'-deoxyguanosine 3',5

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 1999. no 19, 2835-2843 p.
Keyword [en]
NUCLEIC-ACID CONSTITUENTS; METAL-ION-BINDING; COUPLING-CONSTANTS; ANTICANCER DRUGS; AQUEOUS-SOLUTION; TORSION ANGLE; PSEUDOROTATIONAL EQUILIBRIUM; PENTOFURANOSE MOIETY; MAGNETIC-RESONANCE; CHEMICAL SYNTHESIS
Identifiers
URN: urn:nbn:se:uu:diva-27406OAI: oai:DiVA.org:uu-27406DiVA: diva2:55301
Note
Addresses: Plavec J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden. Natl Inst Chem, SI-1115 Ljubljana, Slovenia.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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