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Selective cleavage of the O-6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
1999 (English)In: TETRAHEDRON LETTERS, ISSN 0040-4039, Vol. 40, no 40, 7283-7284 p.Article in journal (Other scientific) Published
Abstract [en]

A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N-2-(Ac or iBu)-O-6-DPC-guanosine to N-2-(Ac or iBu)guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC group followed by treatment with s

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 1999. Vol. 40, no 40, 7283-7284 p.
Keyword [en]
EFFICIENT SYNTHESIS; ANALOGS; DODECARIBONUCLEOTIDE; WINDOW; BLOCKS; DNA
Identifiers
URN: urn:nbn:se:uu:diva-27407OAI: oai:DiVA.org:uu-27407DiVA: diva2:55302
Note
Addresses: Foldesi A, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden. Lajos Kossuth Univ, Dept Organ Chem, H-4010 Debrecen, Hungary.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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