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How kinetically accessible is an RNA target for hybridization with an antisense oligo? A lesson from an RNA target which is as small as a 20mer
Uppsala University.
Uppsala University.
1999 (English)In: TETRAHEDRON, ISSN 0040-4020, Vol. 55, no 5, 1505-1516 p.Article in journal (Other scientific) Published
Abstract [en]

A 20 mer RNA (1), characterized as a duplex with two A.A mismatch basepairs and four tandem G.U wobble basepairs, was targeted at the first A.A internal loop by nonameric 5'-Polyarene DNA-conjugates. For comparison, its DNA counterpart (10), which was fou

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 1999. Vol. 55, no 5, 1505-1516 p.
Keyword [en]
antisense target; polyarenes; DNA conjugates; NUCLEAR-MAGNETIC-RESONANCE; CIRCULAR-DICHROISM; MISMATCHES; DNA; STABILITY; SEQUENCE; NMR; OLIGONUCLEOTIDES; THERMODYNAMICS; TRANSITIONS
Identifiers
URN: urn:nbn:se:uu:diva-27419OAI: oai:DiVA.org:uu-27419DiVA: diva2:55314
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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