Diet and Hip Fracture Risk - A Case-control Study: Study Group of the Multiple Risk Survey on Swedish Women for Eating Assessment
1995 (English)In: International Journal of Epidemiology, ISSN 0300-5771, Vol. 24, no 4, 771-782 p.Article in journal (Other academic) Published
BACKGROUND. The role of diet as a risk factor for osteoporotic fractures is unclear. Earlier studies have yielded conflicting results. METHODS. In two counties in central Sweden we investigated the association between dietary intake and the risk of proximal femoral fractures in a case-control study nested in a cohort. Women born in 1914-1948 were asked to fill out a food frequency questionnaire when invited to attend for mammographic screening between the years 1987 and 1990. More than 65,000 women completed the questionnaire. Those who had participated in the enquiry and subsequently sustained a first hip fracture were defined as cases. For every case, four individually matched controls, by age and county of residence, were selected from the cohort. A second questionnaire concerning confounding factors was mailed to controls and cases. In all, 247 cases and 893 controls could finally be included. Monthly intake of foods and daily intake of nutrients were calculated. RESULTS. When highest quartile of intake was compared to lowest, intakes of iron (adjusted odds ratio [OR] of 3.3, 95% confidence interval [CI]: 1.6-6.9), magnesium (adjusted OR = 2.7, 95% CI: 1.3-6.0) and vitamin C (adjusted OR = 1.9, 95% CI: 1.2-3.1) were found to be independent risk factors for hip fracture. High calcium intake did not protect against hip fracture. Smoking, low physical activity in leisure time, low body mass index, earlier fracture of the distal forearm and diabetes were all risk factors while postmenopausal hormone replacement therapy protected against hip fracture. DISCUSSION. This large study indicates new dietary risk factors for hip fracture. The association between high dietary intake of iron, magnesium and vitamin C and risk of hip fracture has not been reported previously. Further clinical and experimental studies are needed to confirm these findings and to investigate their mechanism of action.
Place, publisher, year, edition, pages
1995. Vol. 24, no 4, 771-782 p.
ASCORBIC ACID; CALCIUM; DIET; HIP FRACTURE; IRON; MAGNESIUM; HORMONE-REPLACEMENT THERAPY; POSTMENOPAUSAL BONE LOSS; POPULATION-BASED COHORT; CALCIUM SUPPLEMENTATION; PHYSICAL-ACTIVITY; IRON-ABSORPTION; RADIAL BONE; CONTROLLED TRIAL; MINERAL DENSITY; PROXI
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-27544PubMedID: 8550275OAI: oai:DiVA.org:uu-27544DiVA: diva2:55439
Addresses: MICHAELSSON K, CENT HOSP VASTERAS, DEPT ORTHOPAED, S-72189 VASTERAS, SWEDEN. CENT HOSP VASTERAS, DEPT RES, S-72189 VASTERAS, SWEDEN. UNIV UPPSALA HOSP, CANC EPIDEMIOL UNIT, S-75185 UPPSALA, SWEDEN. UNIV UPPSALA HOSP, DEPT ORTHOPAED, S-75185 UPP2008-10-172008-10-172009-10-26Bibliographically approved