uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Extensive duplications of phototransduction genes in early vertebrate evolution correlate with block (chromosome) duplications.
2004 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 83, no 5, 852-72 p.Article in journal (Refereed) Published
Abstract [en]

Many gene families in mammals have members that are expressed more or less uniquely in the retina or differentially in specific retinal cell types. We describe here analyses of nine such gene families with regard to phylogenetic relationships and chromosomal location. The families are opsins, G proteins (alpha, beta, and gamma subunits), phosphodiesterases type 6, cyclic nucleotide-gated channels, G-protein-coupled receptor kinases, arrestins, and recoverins. The results suggest that multiple new gene copies arose in all of these families very early in vertebrate evolution during a period with extensive gene duplications. Many of the new genes arose through duplications of large chromosome regions (blocks of genes) or even entire chromosomes, as shown by linkage with other gene families. Some of the phototransduction families belong to the same duplicated regions and were thus duplicated simultaneously. We conclude that gene duplications in early vertebrate evolution probably helped facilitate the specialization of the retina and the subspecialization of different retinal cell types.

Place, publisher, year, edition, pages
2004. Vol. 83, no 5, 852-72 p.
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-181510DOI: 10.1016/j.ygeno.2003.11.008PubMedID: 15081115OAI: oai:DiVA.org:uu-181510DiVA: diva2:556311
Available from: 2012-09-25 Created: 2012-09-25 Last updated: 2017-12-07

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Nordström, Karin

Search in DiVA

By author/editor
Nordström, Karin
In the same journal
Genomics
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 663 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf